BRIEFLY DESCRIBE THE MECHANISMS OF ACTION OF
BRIEFLY DESCRIBE THE MECHANISMS OF ACTION OF
BRIEFLY DESCRIBE THE MECHANISMS OF ACTION OF PIMOBENDAN.Describe the immunologic mechanisms of erythrocyte destruction in immunemediated haemolytic anaemia, differentiating intravascular vs. extravascularhemolysis.
1. Answer all parts of this question:a) Briefly describe the mechanisms of action of pimobendan. (4 marks)b) Describe the indications for pimobendan in dogs based on evidence in theliterature. (8 marks)c) Summarise the literature regarding the use of pimobendan in cats. (5 marks)d) Regarding the drug amiodarone: (7 marks)i. Name the Vaughan Williams classification of this drug.ii. Briefly describe the mechanism of action.iii. Describe the potential indications for this drug in veterinary medicine.2. Regarding a dog undergoing an exploratory celiotomy under general anaesthesia:a) Describe a sound approach to the management of hypotension. (14 marks)b) Describe the abnormalities that would raise suspicion of a diagnosis of malignanthyperthermia. (3 marks)c) Describe the treatment of a dog with suspected malignant hyperthermia.(7 marks)Continued over pageVeterinary Emergency Medicine and Critical Care Paper 1 Page 4 of 53. Answer both parts of this question:a) Describe the pathophysiology of hepatic encephalopathy. (14 marks)b) Discuss medical management of a dog with hepatic encephalopathy.(10 marks)4. Answer all parts of this question:a) Describe the complement cascade and its role in inflammatory and immuneresponses. (12 marks)b) Describe the immunologic mechanisms of erythrocyte destruction in immunemediated haemolytic anaemia, differentiating intravascular vs. extravascularhemolysis. (12 marks)5. Answer all parts of this question:a) Describe the current state of knowledge regarding the syndrome of delayed postoperativebleeding in retired racing greyhounds. (7 marks)b) Explain an evidence based pharmacologic approach to treatment of the syndromeof delayed post-operative bleeding in retired racing greyhounds in Australia.(8 marks)c) List and describe, with explanations of purported etiology, the unique features ofgreyhound dogs compared to other dog breeds that an emergency and criticalcare specialist should be aware of. Do not include discussion of the syndrome ofdelayed post-operative bleeding in this section of your answer. (9 marks)
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