Foundational Neuroscience
Foundational Neuroscience
The Psychiatric mental health practitioners and the staff are supposed to have a very strong foundational neuroscience. The knowledge is useful to help them to diagnose and even treat the treatments of the different psychiatric disorders that are reported. Psychiatric mental health practitioners help in the medications in the process of the treatments of the mental health disorder as well as their impacts on the nervous systems at large. This paper will help to explain the spectrum in the action of the agonist to the antagonist, then compare the works of the ion gated ways and channels to the g couple proteins as well as the roles of the epigenetics that are used in the pharmacologic works and actions.
Most of the involved agents of pharmacological agents work through either being agonist being antagonist receptors that are used to responding to the chemical messengers that are included in the process of neurotransmitters. The agonist is used to bind to the receptors as well as activate the receptor and hence leading to the production of the effects in the cell or the involved biological response (Stefanska & MacEwan, 2015). The pharmacologic agonist binds and even activate the receptors that are called neurotransmitter in the brain like the dopamine receptors which is involved in the schizophrenia.
On the other side, the antagonist will serve by binding to the receptors and then blocking the involved receptors for binding to the agonist without ant biological responses and their effects on the cells. The antagonist stabilizes the receptors which are in the inactive state which is also the same states to the receptors states that are the agonist absence. The other ion gated channels as well as the g couple proteins that are used to represent the two major groups of the receptors of the neurotransmitters (Stahl & Stahl, 2013).
The two groups show the signals transductions mechanism. The ion gated channels are termed as the ion channels that are open while they are responding to the ligand binding. Once the ion gated makes the channels open then the membrane will depolarize and then activating the voltage hated ion that is on the channels to open. When that happens it will make the ions to flow through the involved membranes and then activate the action potential progresses so that to help transmit down the neuron.
While in that activated state, the ions gated channels receptors help to induce changes at a very fast speed within a millisecond in the involved postsynaptic membrane permeability and even the involved potential. The G protein as then the cell surface receptors which are used to share common signaling methods and the structure. All the involved G proteins will bind to the nucleotide guanosine triphosphate (GTP) will hydrolyze and form the guanine diphosphate (GDP).
The GDP will bind to the G protein is the action when the G proteins that are attached to the GDP is inactive. The postsynaptic response that is used by the G protein and the activations which occurs in a slower time than the ion gated channels, this occurs at the time that is in second or even minutes. These are since the G proteins receptors will help to regulate the closing as well as the opening of the ion channels in the indirect ways. The g protein may use the protein kinase so that to establish the sequence that will help to inactivate or activate.
Epigenetics is the genetic data that is always above or even beyond the information that is usually coded by the genetic code. Epigenetics signature has been used to underlie the developmental, diseases and the healthy human changes physiologically which are used to regulate the developments as well as the maintenance of the disease and the phenotype of the healthy cells (Stahl, 2000). Epigenetics regulation that is done by the gene activity is used in the maintenance of the normal cells phenotypic activity and it is used to play a very significant role in the diseases and their developments like Alzheimer’s disease as well as schizophrenia.
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